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OpenSciEd Biology + Earth & Space Unit 3: Inheritance & Variation of Traits Student Edition

Author(s): NATIONAL CENTER FOR

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OpenSciEd High School addresses all high school NGSS standards. This comprehensive science curriculum empowers students to question, design, investigate, and solve the world around them. 

  • Phenomenon Based - Centered around exploring phenomena or solving problems
  • Driven by Student Questions - Storyline based on students’ questions and ideas 
  • Grounded in Evidence - Incremental building and revision of ideas based on evidence 
  • Collaborative - class and teacher figure out ideas together
  • Equitable - Builds a classroom culture that values ideas and learning of all

The OpenSciEd model uses a storyline approach, introducing phenomena that anchors storylines developing disciplinary core ideas, concepts, and science/engineering practices. Students are encouraged to dive deep into key points and solve problems through five activities. 

B.3 Inheritance & Variation of Traits: Who gets cancer and why? What can we do about it?

Who gets cancer and why? What can we do about it? This unit is designed to deepen student understanding of inheritance and variation of traits through an exploration of cancer as a phenomenon. In the first lesson set, students explore the genetic basis of cancer by investigating what cancer is and how mutations that can increase risk for cancer occur. While there are many genes implicated in cancer, the unit focuses on p53, a tumor suppressor gene that is involved in many different cancers. In Lesson Set 2, students investigate cancer caused by mutations that occur throughout our lifetimes, inherited mutations, and how the environment can cause mutations. In the third lesson set, students investigate additional factors that explain differences across the US in both instances of cancer and mortality, access and feasibility of treatment options, and explore the role of health navigator as a way to advocate for and help support friends and family that may be experiencing cancer.

Student Procedures

Lesson 1: Who gets cancer and why?

Lesson 2: What is cancer?

Lesson 3: How do non-cancer cells become cancer cells?

Lesson 4: Why are some kinds of cancer more common than others in older and taller people?

Lesson 5: How do cancer cells end up with differences in their chromosomes and what is the role of p53 in preventing the differences?

Lesson 6: How do we make p53, and why is it different sometimes?

Lesson 7: What is the genetic basis of cancer?

Lesson 8: Why do some cancers appear to run in families?

Lesson 9: How do genes interact with the environment to affect who gets cancer?

Lesson 10: Who gets cancer and why?

Lesson 11: How do cancer treatments work?

Lesson 12: What can we do to support people in our communities who have cancer?

References

US Cancer Data

Age and Height

Mass and Lifespan

Cell Images

Peer Feedback Protocol

Game Board

Cell Cycle Data

Multiple Models

p53 BRCA1 Pedigree

Skin Cancer Data

National Cancer Data

Readings

Incidence of Cancer

Cancer

DNA and Chromosomes

DNA and p53

Passing on Alleles

Skin Cancer Background Reading

Cancer Treatments

Extension: CRISPR-based Therapy

Social Determinants Health 

 

NATIONAL CENTER FOR

OpenSciEd®​ was launched to improve the supply of and address the demand for high-quality, open-source, full course science instructional materials.  The goals of OpenSciEd are to ensure any science teacher, anywhere, can access and download freely available, high quality, locally adaptable materials.  Though the goal of providing full course materials is still a couple of years away, OpenSciEd is releasing six-week units of instruction as they are completed and externally evaluated as quality by Achieve’s Science Peer Review Panel.

OpenSciEd classroom materials are an open education resource and therefore free to download, copy, use, and/or modify.  You can download the instructional materials free of charge at Access Materials page on the OpenSciEd website.

In an effort to lower barriers for all educators to use OpenSciEd, Kendall Hunt and OpenSciEd have partnered to sell high quality printed books, professional learning and lab kits.